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cover such c met inhibitor compound  (Novartis)

 
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    Novartis cover such c met inhibitor compound
    Cover Such C Met Inhibitor Compound, supplied by Novartis, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cover such c met inhibitor compound/product/Novartis
    Average 86 stars, based on 1 article reviews
    cover such c met inhibitor compound - by Bioz Stars, 2026-05
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    (A, B) The proliferation rates of thyroid cancer cell lines and MDA-MB-435 (control melanoma cell line) cultured with increasing concentrations of either <t>Tivantinib</t> (A) or Crizotinib (B) as measured by MTT assay (Material and Methods). Results represent the mean ± SD of MTT experiment results performed in triplicates.
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    (A, B) The proliferation rates of thyroid cancer cell lines and MDA-MB-435 (control melanoma cell line) cultured with increasing concentrations of either Tivantinib (A) or Crizotinib (B) as measured by MTT assay (Material and Methods). Results represent the mean ± SD of MTT experiment results performed in triplicates.

    Journal: Molecular cancer therapeutics

    Article Title: Off Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

    doi: 10.1158/1535-7163.MCT-13-0187

    Figure Lengend Snippet: (A, B) The proliferation rates of thyroid cancer cell lines and MDA-MB-435 (control melanoma cell line) cultured with increasing concentrations of either Tivantinib (A) or Crizotinib (B) as measured by MTT assay (Material and Methods). Results represent the mean ± SD of MTT experiment results performed in triplicates.

    Article Snippet: Compound c-MET inhibitors Tivantinib [ActiveBiochem (Maplewood, NJ)], Crizotinib and SU11274 [Selleck Chemical (Houston, TX)] were suspended in DMSO and stored until use in small aliquots at −20°C.

    Techniques: Control, Cell Culture, MTT Assay

    (A) Cell cycle analysis of SW1737, T2, TL3 thyroid cancer cell lines after treatment with increasing concentrations of Tivantinib and Crizotinib (0.1, 1.0, 10 μM, 24 hours). (B) Graphic display of G2/M data shown on Panel A. (C) Apoptosis measurement (% Annexin V positive cells) after these cells were treated with either Tivantinib or Crizotinib (0.1, 1.0, 10 μM, 24 hours). Results expressed as Mean ± SD. *: P < 0.05; **: P < 0.01.

    Journal: Molecular cancer therapeutics

    Article Title: Off Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

    doi: 10.1158/1535-7163.MCT-13-0187

    Figure Lengend Snippet: (A) Cell cycle analysis of SW1737, T2, TL3 thyroid cancer cell lines after treatment with increasing concentrations of Tivantinib and Crizotinib (0.1, 1.0, 10 μM, 24 hours). (B) Graphic display of G2/M data shown on Panel A. (C) Apoptosis measurement (% Annexin V positive cells) after these cells were treated with either Tivantinib or Crizotinib (0.1, 1.0, 10 μM, 24 hours). Results expressed as Mean ± SD. *: P < 0.05; **: P < 0.01.

    Article Snippet: Compound c-MET inhibitors Tivantinib [ActiveBiochem (Maplewood, NJ)], Crizotinib and SU11274 [Selleck Chemical (Houston, TX)] were suspended in DMSO and stored until use in small aliquots at −20°C.

    Techniques: Cell Cycle Assay

    Cells were pre-starved in culture medium containing 0.5% FBS (24 hour) ± either Crizotinib or Tivantinib (0.1, 1.0, 10 μM) or SU11274 (10 μM), and stimulated with 20 ng/ml recombinant human HGF for 10 minutes before lysates were made for western blotting. A series of c-MET downstream signaling pathway proteins and phosphor-proteins were detected using western blotting. β-actin was used as a loading balance control.

    Journal: Molecular cancer therapeutics

    Article Title: Off Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

    doi: 10.1158/1535-7163.MCT-13-0187

    Figure Lengend Snippet: Cells were pre-starved in culture medium containing 0.5% FBS (24 hour) ± either Crizotinib or Tivantinib (0.1, 1.0, 10 μM) or SU11274 (10 μM), and stimulated with 20 ng/ml recombinant human HGF for 10 minutes before lysates were made for western blotting. A series of c-MET downstream signaling pathway proteins and phosphor-proteins were detected using western blotting. β-actin was used as a loading balance control.

    Article Snippet: Compound c-MET inhibitors Tivantinib [ActiveBiochem (Maplewood, NJ)], Crizotinib and SU11274 [Selleck Chemical (Houston, TX)] were suspended in DMSO and stored until use in small aliquots at −20°C.

    Techniques: Recombinant, Western Blot, Control

    Tivantinib and Crizotinib inhibition (IC50) of p-MET and cell growth of cancer cells.

    Journal: Molecular cancer therapeutics

    Article Title: Off Target Effects of c-MET Inhibitors on Thyroid Cancer Cells

    doi: 10.1158/1535-7163.MCT-13-0187

    Figure Lengend Snippet: Tivantinib and Crizotinib inhibition (IC50) of p-MET and cell growth of cancer cells.

    Article Snippet: Compound c-MET inhibitors Tivantinib [ActiveBiochem (Maplewood, NJ)], Crizotinib and SU11274 [Selleck Chemical (Houston, TX)] were suspended in DMSO and stored until use in small aliquots at −20°C.

    Techniques: Inhibition